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EC number: 500-465-4 | CAS number: 160901-28-0 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Species:
- human
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Skin region: abdomen
BMI: 22.7-35.5 - Type of coverage:
- occlusive
- Vehicle:
- other: HBSS-buffer
- Duration of exposure:
- 24 h
- Doses:
- 10%
- No. of animals per group:
- 3 donors (n=2)
- Control animals:
- no
- Details on study design:
- According to Guideline.
- Absorption in different matrices:
- The mean amount of sodium laureth sulfate (SLS) removed from the skin surface (skin wash) ranged from 87.16% to 94.56% of the dose applied in the mean values of the 3 skin donors. This demonstrates that the SLS has mostly remained on the skin surface. The amounts in the receptor could not be quantified, since it was below the analytical lower limit of quantification (LLOQ). The mean recovery in the two first tape strips was 1.48% during all performed experiments. In the further 18 tape strips a mean recovery of 2.86% was documented. The recovery values for the cryocuts have accounted 0.56% in mean. The mean recovery values have varied from 90.90% to 100.21%, which complies to the acceptance criteria of 100 ± 15%.
The mean absorbed dose of SLS, sum of the amounts found in the viable epidermis, dermis and receptor medium was 0.56%. - Total recovery:
- 90.90% - 100.21%
- Dose:
- 10%
- Parameter:
- percentage
- Absorption:
- < 1 %
- Remarks on result:
- other: 24 h
- Remarks:
- The mean absorbed dose of SLS, sum of the amounts found in the viable epidermis, dermis and receptor medium was 0.56%.
- Conclusions:
- The mean absorbed dose of sodium laureth sulfate (SLS), sum of the amounts found in the viable epidermis, dermis and receptor medium and the mean recovery of SLS found in the deeper skin layers sum up to 0.56%.
Data source
Materials and methods
Test material
- Reference substance name:
- Alcohols, C9-11, branched and linear, ethoxylated, sulfates, sodium salts
- EC Number:
- 500-465-4
- EC Name:
- Alcohols, C9-11, branched and linear, ethoxylated, sulfates, sodium salts
- Cas Number:
- 160901-28-0
- Molecular formula:
- CnH2n+1(OCH2CH2)mOSO3Na; n = 9 - 11, m = 1 - 2.5
- IUPAC Name:
- Alcohols, C9-11, branched and linear, ethoxylated, sulfates, sodium salts
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Skin region: abdomen
BMI: 22.7-35.5
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: HBSS-buffer
- Duration of exposure:
- 24 h
- Doses:
- 10%
- No. of animals per group:
- 3 donors (n=2)
- Control animals:
- no
- Details on study design:
- According to Guideline.
Results and discussion
- Absorption in different matrices:
- The mean amount of sodium laureth sulfate (SLS) removed from the skin surface (skin wash) ranged from 87.16% to 94.56% of the dose applied in the mean values of the 3 skin donors. This demonstrates that the SLS has mostly remained on the skin surface. The amounts in the receptor could not be quantified, since it was below the analytical lower limit of quantification (LLOQ). The mean recovery in the two first tape strips was 1.48% during all performed experiments. In the further 18 tape strips a mean recovery of 2.86% was documented. The recovery values for the cryocuts have accounted 0.56% in mean. The mean recovery values have varied from 90.90% to 100.21%, which complies to the acceptance criteria of 100 ± 15%.
The mean absorbed dose of SLS, sum of the amounts found in the viable epidermis, dermis and receptor medium was 0.56%. - Total recovery:
- 90.90% - 100.21%
Percutaneous absorption
- Dose:
- 10%
- Parameter:
- percentage
- Absorption:
- < 1 %
- Remarks on result:
- other: 24 h
- Remarks:
- The mean absorbed dose of SLS, sum of the amounts found in the viable epidermis, dermis and receptor medium was 0.56%.
Applicant's summary and conclusion
- Conclusions:
- The mean absorbed dose of sodium laureth sulfate (SLS), sum of the amounts found in the viable epidermis, dermis and receptor medium and the mean recovery of SLS found in the deeper skin layers sum up to 0.56%.
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