Registration Dossier
Registration Dossier
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EC number: 200-400-7 | CAS number: 58-86-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
- Justification for type of information:
- QSAR prediction
- Principles of method if other than guideline:
- ECOSAR v1.11
QMRF and QPRF are attached in IUCLID - GLP compliance:
- not specified
- Test organisms (species):
- other: green algae
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 130 000 mg/L
- Remarks on result:
- other: using the estimated KOWWIN LogKow of -2.91
- Validity criteria fulfilled:
- yes
- Conclusions:
- 96-hr EC50: 1.3E+05 mg/L
- Executive summary:
The ECOSAR 96-hr EC50 for green algae was predicted to be 1.3E+05 mg/L.
The ECOSAR Neutral Organics Green Algae 96-h EC50 is a valid model in accordance with the OECD principles. An evaluation of its training set was made for the purposes of evaluating the applicability domain. The test substance satisfies the structural domain of the KOWWIN model that is used to derive the LogKow input variable. The test substance satisfies the descriptor range as defined by the MW range of the training set. The test substance satisfies the mode of action as being a neutral organic as determined by the OECD Toolbox v3.0. Thus the test substance satisfies the applicability domain requirement of this model. Adequate documentation has been provided by way of the QPRF and the associated QMRF for 'ECOSAR Neutral Organics Green Algae 96-h' model.
Reference
Supporting documentation is provided in the attached QPRF and QMRF.
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 130 000 mg/L
Additional information
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