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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
ECOSAR v1.11
QMRF and QPRF are attached in IUCLID
GLP compliance:
not specified
Test organisms (species):
Daphnia magna
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
1 130 000 mg/L
Basis for effect:
mortality
Remarks on result:
other: using the estimated KOWWIN LogKow of -2.91

Supporting documentation is provided in the attached QPRF and QMRF.

Validity criteria fulfilled:
yes
Conclusions:
48-hr LC50: 1.13E+06 mg/L
Executive summary:

The ECOSAR 48-hr LC50 for Daphnia magna was predicted to be 1.13E+06 mg/L.

 

The neutral organics model for 48-hr Daphnia magna as housed within the ECOSAR v1.11 is a valid model in accordance with the OECD principles. The model relies upon KOWWIN v1.68 for its LogKow estimates. KOWWIN v1.68 has been evaluated previously and is described in a separate QMRF. The test substance is a general narcotic and its MW and LogKow values lie within the boundaries of the training set. Thus the test substance satisfies the applicability domain requirement to a sufficient extent. Other hydrophilic analogues were conservatively estimated by ECOSAR. Thus the test substance satisfies the applicability domain requirement to a sufficient extent. Adequate documentation has been provided by way of the QPRF, the associated QMRF ‘ECOSAR Neutral Organics Daphnid 48-h LC50’ and that of KOWWIN v1.68.

 

Description of key information

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1 130 000 mg/L

Additional information