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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation. This study is used to provide a weight of evidence for the hazard endpoint that is sufficient for the purpose of classification and labelling and/or risk assessment. Other studies on this endpoint are included.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2012

Materials and methods

Principles of method if other than guideline:
OECD Toolbox v2.3
Toolbox prediction report is attached in IUCLID
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES:C{P+}1(O)C{P+}(O)C{P-}(O)C{P+}(O)CO1

Method

Species / strain
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
without

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
without
Genotoxicity:
negative

Any other information on results incl. tables






Estimation method: (Q)SAR prediction
In domain

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative without metabolic activation

This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
The prediction without metabolic activation was negative.
Executive summary:

The TIMES model for Ames mutagenicity was used within the OECD Toolbox v2.3. The prediction without metabolic activation was negative. Additional supporting documentation is provided in the attached prediction report.