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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation. This study is used to provide a weight of evidence for the hazard endpoint that is sufficient for the purpose of classification and labelling and/or risk assessment. Another study on this endpoint is included.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Principles of method if other than guideline:
OECD Toolbox v3.1
Toolbox prediction report is attached in IUCLID
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES:C1(O)C(O)C(O)C(O)CO1

Test animals

Species:
other: Rabbit; Human

Test system

Type of coverage:
other: no data; occlusive

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Score:
< 2

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"

Estimation method: Takes average value from the 5 nearest neighbours

Domain  logical expression:Result: In Domain

 

(("a" and "b") and("c" and "d") )

 

Domain logical expression index: "a"

 

Referential boundary:The target chemical should be classified as Neutral Organics by Aquatic toxicity classification by ECOSAR ONLY

 

Domain logical expression index: "b"

 

Referential boundary:The target chemical should be classified as Discrete chemical by Substance Type

 

Domain logical expression index: "c"

 

Parametric boundary:The target chemical should have a value of log Kow which is >= -3.9

 

Domain logical expression index: "d"

 

Parametric boundary:The target chemical should have a value of log Kow which is <= -1.55

 

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information expert judgement Criteria used for interpretation of results: expert judgment
Conclusions:
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).

Primary (Dermal) Irritation Index (PII): <2; Slightly irritating based on expert judgement
Executive summary:

A Primary Irritation Index (PII) value less than 2 was derived by QSAR using the OECD Toolbox. The model was based on in vivo rabbit skin irritation using the five nearest neighbours. The test substance was determined to be slightly irritating to the skin based on expert judgement. Supporting documentation is provided in the attached prediction report..