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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Principles of method if other than guideline:
OECD Toolbox v3.1
Toolbox prediction report is attached in IUCLID
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Xylose
EC Number:
200-400-7
EC Name:
Xylose
Cas Number:
58-86-6
Molecular formula:
C5H10O5
IUPAC Name:
xylose
Details on test material:
SMILES:C1(O)C(O)C(O)C(O)CO1

Test animals

Species:
other: Rabbit; Human

Test system

Type of coverage:
other: no data; occlusive

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Score:
< 2

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"

Estimation method: Takes average value from the 5 nearest neighbours

Domain  logical expression:Result: In Domain

 

(("a" and "b") and("c" and "d") )

 

Domain logical expression index: "a"

 

Referential boundary:The target chemical should be classified as Neutral Organics by Aquatic toxicity classification by ECOSAR ONLY

 

Domain logical expression index: "b"

 

Referential boundary:The target chemical should be classified as Discrete chemical by Substance Type

 

Domain logical expression index: "c"

 

Parametric boundary:The target chemical should have a value of log Kow which is >= -3.9

 

Domain logical expression index: "d"

 

Parametric boundary:The target chemical should have a value of log Kow which is <= -1.55

 

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Primary (Dermal) Irritation Index (PII): <2; Slightly irritating based on expert judgement
Executive summary:

A Primary Irritation Index (PII) value less than 2 was derived by QSAR using the OECD Toolbox. The model was based on in vivo rabbit skin irritation using the five nearest neighbours. The test substance was determined to be slightly irritating to the skin based on expert judgement. Supporting documentation is provided in the attached prediction report..