Registration Dossier
Registration Dossier
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EC number: 200-400-7 | CAS number: 58-86-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- OECD Toolbox v3.1
Toolbox prediction report is attached in IUCLID - GLP compliance:
- not specified
Test material
- Reference substance name:
- Xylose
- EC Number:
- 200-400-7
- EC Name:
- Xylose
- Cas Number:
- 58-86-6
- Molecular formula:
- C5H10O5
- IUPAC Name:
- (2S,3R,4S; 5R)-oxane-2,3,4,5-tetrol
- Details on test material:
- SMILES:C1(O)C(O)C(O)C(O)CO1
Constituent 1
Test animals / tissue source
- Species:
- other: Rabbit
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Score:
- 1.86
- Remarks on result:
- other: MMAS (modified maximum average score)
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: Out of Domain
(("a" and "b") and("c" and "d") )
Domain logical expression index: "a"
Referential boundary:The target chemical should be classified as Neutral Organics by Aquatic toxicity classification by ECOSAR ONLY
Domain logical expression index: "b"
Referential boundary:The target chemical should be classified as Discrete chemical by Substance Type
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.65
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= -0.621
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- MMAS (modified maximum average score) = 1.86, Slightly irritating based on expert judgement
- Executive summary:
A MMAS (modified maximum average score) of 1.86 was derived by QSAR using the OECD Toolbox. The model was based on in vivo rabbit eye irritation using the five nearest neighbours. The test substance was determined to be slightly irritating to the eye based on expert judgement. Supporting documentation is provided in the attached prediction report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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