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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
8.11.2019 - 17.2.2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
309 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
72 h
Temp.:
29.8 °C
pH:
4
Key result
Water solubility:
274 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
72 h
Temp.:
29.8 °C
pH:
7
Key result
Water solubility:
274 mg/L
Conc. based on:
test mat. (dissolved fraction)
Incubation duration:
72 h
Temp.:
29.8 °C
pH:
9
Conclusions:
Using the flask method ist was shown that the solubility of 2-amino-5-chloro-N,3-dimethylbenzamide shows pH dependance ranging from 309 mg/L (pH = 4) to 264 mg/L (pH = 9).
Executive summary:

The objective of this study is to determine the solubility in water of 2-AMINO-5CHLORO-N,3-DIMETHYLBENZAMIDE following the Regulation (EC) No.1907/2006 - and Council regulation (EC) No. 260/2014 - EC A.6. method (2014) and OECD  Guideline No. 105 (1995).

The solubility of 2 -AMINO-5 -CHLORO-N,3DIMETHYLBENZAMIDE in water performed at three pH (4, 7 and 9) was as followed:

pH (4) = 309 mg/L

pH(7) = 274 mg/L

pH (9) = 264 mg/L

Description of key information

The objective of this study was to determine the solubility of 2 -AMINO-5CHLORO-N,3 -DIMETHYLBENZAMIDE

in water following the Regulation (EC) No.1907/2006 - and Council regulation (EC) No. 260/2014 - EC A.6. method (2014) and OECD  Guideline No. 105 (1995).

The solubility of 2 -AMINO-5 -CHLORO-N,3DIMETHYLBENZAMIDE in water performed at three pH (4, 7 and 9) is determined to:

pH (4) = 309 mg/L

pH(7) = 274 mg/L

pH (9) = 264 mg/L

Key value for chemical safety assessment

Water solubility:
274 mg/L
at the temperature of:
29.8 °C

Additional information