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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 November 2019 to 16 December 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
OECD Guideline No. 117 (2004)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Identification: 2-AMINO-5-CHLORO-N,3-DIMETHYLBENZAMIDE
Batch: 628-042-00
CAS number: [890707-28-5]
Purity: 99.0 %
Analysis date: 16 October 2019
Expiry date: 16 October 2021
Supplier: ADAMA Makhteshim Ltd.
Appearance: Beige powder
Packaging: White opaque plastic bag
Quantity: received 1 kg
Date of receipt: 12 November 2019
Storage: In darkness at room temperature
gIdentification number: 19-193
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.7
Temp.:
25 °C
Remarks on result:
other: pH value was not measured, diluent is between pH 6 and 7 and transferable to complete solution
Conclusions:
By HPLC method the octanol/water partition coefficient of 2-Amino-5-chloro-N,3-dimethylbenzamide is equal to 1.7.
Executive summary:

By HPLC method accoding to regulation (EC) No. 2016/266 - EC A.24. method (2016) and OECD Guideline No. 117 (2004) the partisition coefficient for 2-Amino-5-chloro-N,3-dimethylbenzamide was determined to be equal to 1.7.

Description of key information

For 2-Amino-5-chloro-N,3-dimethylbenzamide by application of (EC) No. 2016/266 - EC A.24. method (2016) and using the HPLC test method OECD Guideline No. 117 (2004), it was shown that the the octanol/water partition coefficient of is equal to 1.7.

The partition coefficient is in good agreement with screening tests of solubility in organc solvents.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.7
at the temperature of:
25 °C

Additional information