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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-benzoylbenzoic acid
EC Number:
201-612-2
EC Name:
2-benzoylbenzoic acid
Cas Number:
85-52-9
Molecular formula:
C14H10O3
IUPAC Name:
2-benzoylbenzoic acid

In vitro test system

Test system:
human skin model
Source species:
human
Vehicle:
unchanged (no vehicle)
Details on test system:
The test item was applied as supplied
Control samples:
yes, concurrent negative control
yes, concurrent positive control
Amount/concentration applied:
16 mg
Duration of treatment / exposure:
42 min
Duration of post-treatment incubation (if applicable):
42h
Number of replicates:
3

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
Test item - Mean percent viability
Value:
89.1
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
Test item - Run 1
Value:
100.4
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
Test item - Run 2
Value:
89
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
Test item - Run 3
Value:
78
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
Negative control - Mean percent viability
Value:
100
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
Positive control - Mean percent viability
Value:
1.8
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The skin irritation potential was tested according to OECD 439 guideline on reconstructed human epidermis. The mean percent viability of the treated tissues was 89.1%. In accordance with the regulation EC n°1272/2008, the test item has to be considered as non-irritant to skin. It corresponds to UN GHS No category.
Executive summary:

The skin irritation potential was tested according to OECD 439 guideline on reconstructed human epidermis. The mean percent viability of the treated tissues was 89.1%. In accordance with the regulation EC n°1272/2008, the test item has to be considered as non-irritant to skin. It corresponds to UN GHS No category.