Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: Literature
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Acute oral toxicity of 2-benzoylbenzoic acid
Author:
Not specified
Year:
1971
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(11), Pg. 52, 1971.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-benzoylbenzoic acid
EC Number:
201-612-2
EC Name:
2-benzoylbenzoic acid
Cas Number:
85-52-9
Molecular formula:
C14H10O3
IUPAC Name:
2-benzoylbenzoic acid
Test material form:
solid: particulate/powder

Test animals

Details on test animals or test system and environmental conditions:
Several animals tested : rat and mouse

Administration / exposure

Route of administration:
other: not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
rat
Effect level:
880 mg/kg bw
Sex:
not specified
Dose descriptor:
LD50
Remarks:
mouse
Effect level:
4 600 mg/kg bw
Clinical signs:
muscle weakness

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Gigiena Truda i Professional'nye Zabolevaniya presents a study on acute exposure of rats and mice to 2-benzoylbenzoic acid. This study shows the following resultas :
Oral / LD50 (rat) : 880 mg/kg
Oral / LD50 (mouse) : 4600 mg/kg
Regarding theses results, the substance is classified in the category 4 based on GHS criteria.
Executive summary:

Gigiena Truda i Professional'nye Zabolevaniya presents a study on acute exposure of rats and mice to 2-benzoylbenzoic acid. This study shows the following resultas :

Oral / LD50 (rat) : 880 mg/kg

Oral / LD50 (mouse) : 4600 mg/kg

Regarding theses results, the substance is classified in the category 4 based on GHS criteria.