Registration Dossier
Registration Dossier
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EC number: 201-612-2 | CAS number: 85-52-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Dec 2018 to 25 Jan 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: Off-white powder
Purity/Composition: 98.8%
Test item storage: At room temperature - Key result
- Water solubility:
- 0.284 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 3.6 - <= 3.7
- Conclusions:
- The flask method was applied for the determination of the water solubility of 2-Benzoylbenzoic acid.
The water solubility of the test item at 20°C was 0.284 g/L.
The pH of the aqueous samples was 3.6 and 3.7. - Executive summary:
In this guideline (OECD 105) study conducted with GLP certification, the water solubility of the test material (EC 201-612-2) at 20°C was determined to be 0.284 g/L.
Reference
Preliminary Test
The content of test item dissolved in the water sample was 0.357 g/L.
Main Study
The results for the samples taken at 24, 48 and 72 hours are given in Table 6.
The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations.
A small response at the retention time of the test item was detected in the chromatogram of the pretreated sample from the blank water mixture. The maximum contribution to the samples was 0.0017%. It was considered that it has no significant effect on the results of the test samples.
Table 6
Water Solubility of the Test Item
| Stirring time [hours] | Analyzed concentration [g/L] | Mean [g/L] | Maximum difference [%] | pH |
| 24 | 0.283 | 0.284 | 1.3 | 3.6 |
| 48 | 0.284 | 3.7 | ||
| 72 | 0.286 | 3.6 |
Description of key information
Study conducted to recognised testing guidelines with GLP certification.
Key value for chemical safety assessment
- Water solubility:
- 0.284 g/L
- at the temperature of:
- 20 °C
Additional information
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