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EC number: 459-520-5
CAS number: 132182-92-4
acute inhalation toxicity of T-7869 was
evaluated in male Sprague Dawley rats. The
study method was based on a custom protocol. A group of 4 male rats rats
were exposed, whole body, to an atmosphere of 30,000 ppm T-7869 (430
mg/L, vapor) for
4 hours. A
second group of 4 rats served as a control group and were exposed to an
atmosphere containing no test material. Observations
were made continually
during the study. Urine samples were collected every 24 hours for 2
consecutive days post-exposure and analyzed for metabolites via NMR.
were recorded at pre-test, daily, and at termination.After
the 14 day observation period, all animals were euthanized and gross
necropsy was performed.
The organ weights of the liver, kidneys, and testes were recorded.
All animals survived. There
were no abnormal clinical observations, changes
in body weight, necropsy findings, or changes in organ weights. There
was 20.49 ug (less than 0.0001% of theoretical maximum) of the test
in the urine after 24 hours, and none was detected after 48 hours (below
the limit of detection), indicating that T-7869 undergoes very limited metabolism.
Based on the results of the study, the 4 hour acute inhalation
LC50 in male rats was greater than 428 mg/L (vapor) (30,000 ppm) and the
test article is not classified for acute inhalation lethality according
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