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Physical & Chemical properties

Water solubility

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Description of key information

Water solubility of HFE-7300 is determined to be 295 µg/L at 30 °C.

Key value for chemical safety assessment

Additional information

Two studies were conducted to determine the water solubility of HFE-7300.

The solubility of HFE-7300 in Milli-Q water was determined in 2012 using the Shake Flask method according to OPPTS 830.7840. Triplicate samples were incubated for 1, 2, and 3 days at approximately 30 °C. Samples were equilibrated at room temperature for 24 hours prior to analysis by purge and trap gas chromatography/mass spectrometry (GC/MS). HFE-7300 has an average measured water solubility of 295 µg/L at approximately 30˚C, the overall %RSD was 10%. This is a guideline study conducted under GLP compliance. It is considered reliable without restriction. This study uses better technology and analytical method for handling volatile organic compound. Therefore, it is considered a key study.

A previous study was conducted in 2003 using the Shake Flask method according to OPPTS 830.7840. Triplicate samples containing HFE-7300 were incubated for 4, 5, and 6 days at approximately 30 °C. Samples were equilibrated at room temperature for 24 hours prior to analysis by purge and trap gas chromatography/mass spectrometry (GC/MS). HFE-7300 had an average measured water solubility of 586 µg/L at approximately 30˚C. The overall %RSD was 5.6%. This is a guideline study conducted under GLP compliance. The study meets test requirements with no deviation. Therefore, it is considered reliable without restrictions and a supporting study.

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