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Administrative data

Endpoint:
Henry's law constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 September 2012 - 04 October 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and under GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: calculation based on experimental data
Deviations:
not applicable
Principles of method if other than guideline:
Henry's Law Constant was determined by measuring the Novec 7300 concentrations in gas-phase and in aqueous-phase for a given test system vessel at equilibrium conditions and at ambient temperature and pressure.
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Novec 7300
IUPAC Name:
Novec 7300
Details on test material:
- Name of test material (as cited in study report): Novec 7300
- Physical state: Colorless, clear liquid
- Analytical purity: 99.85%

Results and discussion

Henry's Law constant H
H:
2 770 dimensionless
Temp.:
22 °C
Atm. press.:
760 mm Hg

Any other information on results incl. tables

Henry's Law constant (HLC) result is reported as a dimensionless ratio of headspace concentration of Novec 7300 over aqueous phase concentration.

The average Henry's Law constant for Novec 7300 was 2770, with %RSD of 4.9% (Table 1). The Henry's Law constant expressed as log HLC is 3.4, with %RSD of 0.61% (Table 2).

All measured water concentrations of Novec 7300 were approximately 5 ng/mL, which was well below the measured water solubility of 295 ng/mL (10% RSD). These water levels indicate that the Novec 7300 dosing gas did not produce a saturated system at equilibrium.

Henry’s Law constants were also measured for tetrafluoroethylene (TFE) using the same analytical approach for Novec 7300 to demonstrate the validity of the analytical techniques. In this study, the log HLC for TFE was 1.5 (%RSD = 2.6) for test vessels containing approximately 50% headspace. The TFE result was within 10% of the literature value.

Table 1: Summary of Henry’s Law Constant (HLC) for Novec 7300

 

Ratio

(Headspace: Aqueous)

Replicate

 

Time point 1

(Three days)

 

Time point 2

(Four days)

 

Time point 3

(Five days)

70 %

Headspace

1

2810

2680

2640

2

2950

2660

2640

Average

2880

2670

2640

%RPD

4.9

0.75

0

50 %

Headspace

1

N/A*

2680

2660

2

3030

2590

2680

Average

3030

2640

2670

%RPD

N/A

3.4

0.75

30 %

Headspace

1

2890

2800

2800

2

3020

2800

2710

Average

2960

2800

2760

%RPD

4.4

0

3.3

Intra-Time Point Average

% RSD

2940

3.1

2700

3.1

2690

2.3

Overall Average

%RSD

2770

4.9

 

·       ThekH,ccfor Replicate 1 was determined to be a statistical outlier using the Dixon’s Q test and was

Excluded from the determination of the averagekH,ccvalue.

Table 2: Summary of Log (HLC) for Novec 7300

 

Ratio

(Headspace: Aqueous)

Replicate

 

Time point 1

(Three days)

 

Time point 2

(Four days)

 

Time point 3

(Five days)

70 %

Headspace

1

3.4

3.4

3.4

2

3.5

3.4

3.4

Average

3.5

3.4

3.4

%RPD

0.61

0.09

0.00

50 %

Headspace

1

NR*

3.4

3.4

2

3.5

3.4

3.4

Average

3.5

3.4

3.4

%RPD

NA

0.43

0.09

30 %

Headspace

1

3.5

3.4

3.4

2

3.5

3.4

3.4

Average

3.5

3.4

3.4

%RPD

0.55

0.0

0.41

Intra-Day Average

% RSD

3.5

0.40

3.4

0.39

3.4

0.28

Overall Average

%RSD

3.4

0.61

 

·       The water concentrations measured for Vial 1, 50% headspace, Time Point 1 was determined to be a

Statistical outlier using the Dixon’s Q-test. The log(kH,cc) value is not reported for this test system vial.

Applicant's summary and conclusion

Conclusions:
The log Henry's Law constant (HLC) for Novec 7300 was determined to be 3.4 at 22 °C.
Executive summary:

The Henry's Law constant of Novec 7300 was determined by the ratio of headspace concentration over aqueous phase concentration.

Duplicate test vessels were filled with water and dosed with Novec 7300 gas at each of three different headspace:water ratios (70%, 50% and 30%). The vials were incubated for 3, 4, and 5 days at ambient temperature. Both the headspace and the water phase for each vial were sampled and analyzed in duplicates using gas chromatography/mass spectrometry (GC/MS). The average measured gas phase and water phase concentrations were used to calculate Henry's Law constant for Novec 7300 for each test vessel.

The average Henry's Law constant for Novec 7300 was 2770 at 22 °C.

The Henry's Law constant expressed as log HLC is 3.4 at 22 °C. This study was conducted under GLP compliance with accepted method. Therefore, it is considered reliable without restrictions.

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