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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
Work performed in manufacturer's laboratories using well established methods
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
no
Specific details on test material used for the study:

Batch number of test material: C-04-3584
Dissociating properties:
yes
No.:
#1
pKa:
0.002
Temp.:
20 °C

Titration

 

V, mL

pH

DV

DpH

DpH/DV

0.00

2.18

1.00E+00

5.0000E-02

5.00E-02

1.00

2.23

2.00E+00

5.0000E-02

2.50E-02

3.00

2.28

2.00E+00

6.0000E-02

3.00E-02

5.00

2.34

2.00E+00

1.2000E-01

6.00E-02

7.00

2.46

2.00E+00

1.0000E-01

5.00E-02

9.00

2.56

2.00E+00

1.3000E-01

6.50E-02

11.00

2.69

2.00E+00

1.8000E-01

9.00E-02

13.00

2.87

2.00E+00

2.2000E-01

1.10E-01

15.00

3.09

2.00E+00

4.0000E-01

2.00E-01

17.00

3.49

2.00E+00

1.0700E+00

5.35E-01

19.00

4.56

1.00E+00

1.4500E+00

1.45E+00

20.00

6.01

5.00E-01

8.1000E-01

1.62E+00

20.50

6.82

5.00E-01

7.2000E-01

1.44E+00

21.00

7.54

5.00E-01

5.4000E-01

1.08E+00

21.50

8.08

5.00E-01

4.1000E-01

8.20E-01

22.00

8.49

5.00E-01

3.5000E-01

7.00E-01

22.50

8.84

5.00E-01

2.7000E-01

5.40E-01

23.00

9.11

5.00E-01

2.1000E-01

4.20E-01

23.50

9.32

5.00E-01

1.4000E-01

2.80E-01

24.00

9.46

1.00E+00

2.8000E-01

2.80E-01

25.00

9.74

1.00E+00

1.3000E-01

1.30E-01

26.00

9.87

1.00E+00

2.1000E-01

2.10E-01

27.00

10.08

1.00E+00

1.4000E-01

1.40E-01

28.00

10.22

1.00E+00

2.9000E-01

2.90E-01

29.00

10.51

1.00E+00

2.6000E-01

2.60E-01

30.00

10.77

1.00E+00

2.9000E-01

2.90E-01

31.00

11.06

-3.10E+01

-1.1060E+01

3.57E-01

 

Conclusions:
The substance dissociates under all normal environmental and biological conditions.

Description of key information

Key value for chemical safety assessment

pKa at 20°C:
0.001

Additional information