Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information

No clinical signs or effects on reproduction or development were reported.

The No Observed Adverse Effect Level (NOAEL) for repeated dose toxicity, reproductive toxicity and for developmental toxicity was considered to be in excess of 1000 mg/kg bw/day zirconium acetate anhydrous.

This equates to ca. 280 mg/kg/day Zr 4+ and in turn, using a nominal molecular weight of 231 for the registered substance, the NOAEL for the zirconium oxynitrate is greater than 700 mg/kg/day

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
700 mg/kg bw/day
Study duration:
subacute
Species:
rat

Justification for classification or non-classification