Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Cross-reference
Reason / purpose:
data waiving: supporting information
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
In-house data assessment.
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 105 (Water Solubility)
Principles of method if other than guideline:
Solubility at range of pH was investigated as has relevance for environmental and toxicological assessments.
GLP compliance:
no
Type of method:
other: Observations
Specific details on test material used for the study:
Batch number of test material: C-04-3584
Key result
Water solubility:
ca. 1 000 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 1.2
Remarks on result:
completely miscible
Remarks:
pH unadjusted
Water solubility:
> 50 g/L
Conc. based on:
test mat. (total fraction)
Temp.:
20 °C
pH:
ca. 1.5
Remarks on result:
other: pH buffered for evaluation of solubility at different pH
Conclusions:
The solubility is pH dependant with reduced solublity at pH 5 or more, suggesting formation of hydroxide / oxide
The substance supplied is typically in acidic solution

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion