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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Zirconium lactate and barium zirconate: Acute toxicity and inhalation effects in experimental animals.
Author:
Brown, JR; Mastromatteo, E; Horwood, J.
Year:
1963
Bibliographic source:
Am Ind Hyg Assoc J 24(2):131−136.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute oral toxicity tests were carried out on 4 groups of six male Wistar rats. Test material was administered as a suspension in corm oil by stomach tube. The LD50 doses were calculated from the tables published by Weil.
GLP compliance:
no
Remarks:
Study pre-dates the introduction of GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Zirconium lactate
Cas Number:
60676-90-6
Molecular formula:
C12H20O12Zr
IUPAC Name:
Zirconium lactate
Specific details on test material used for the study:
Zirconium lactate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
Oral doses of 0.75, 1.5, 3.0 and 6.0 g/kg of body weight were given as range-finding doses.
Groups of six rats were then given graduated doses of 1.25, 2.5, 5.0 and 10.0 g/kg of zirconium lactate.
No. of animals per sex per dose:
6 male rats per dose.
Control animals:
not specified
Statistics:
The LD50 doses were calculated from the tables published by Weil

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In a study in male Wistar rats, the oral LD50 was found to be > 10 000 mg/kg bw, the maximum dose tested.
Executive summary:

Groups of male Wistar rats were administered zirconium lactate suspended in corn oil at doses of 1.25, 2.5, 5.0 and 10.0 g/kg. The oral LD50 was found to be greater than the maximum dose tested, i.e. > 10 g/kg bw.