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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Zirconium lactate and barium zirconate: Acute toxicity and inhalation effects in experimental animals.
Author:
Brown, JR; Mastromatteo, E; Horwood, J.
Year:
1963
Bibliographic source:
Am Ind Hyg Assoc J 24(2):131−136.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute oral toxicity tests were carried out on 4 groups of six male Wistar rats. Test material was administered as a suspension in corm oil by stomach tube. The LD50 doses were calculated from the tables published by Weil.
GLP compliance:
no
Remarks:
Study pre-dates the introduction of GLP
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Zirconium lactate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
Oral doses of 0.75, 1.5, 3.0 and 6.0 g/kg of body weight were given as range-finding doses.
Groups of six rats were then given graduated doses of 1.25, 2.5, 5.0 and 10.0 g/kg of zirconium lactate.
No. of animals per sex per dose:
6 male rats per dose.
Control animals:
not specified
Statistics:
The LD50 doses were calculated from the tables published by Weil

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In a study in male Wistar rats, the oral LD50 was found to be > 10 000 mg/kg bw, the maximum dose tested.
Executive summary:

Groups of male Wistar rats were administered zirconium lactate suspended in corn oil at doses of 1.25, 2.5, 5.0 and 10.0 g/kg. The oral LD50 was found to be greater than the maximum dose tested, i.e. > 10 g/kg bw.