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Reliable and GLP-conform acute toxicity studies of m-toluic acid are available for algae, daphnia, and fish. Algae appear to be most sensitive; the 72-h EC50 for P. subcapitata amounts to 18 mg/L. A 48-h EC50 of 75 mg/L was derived for the immobilisation of Daphnia magna and a 96-h LC50 of 82 mg/L for fish (Oryzias latipes).

Regarding chronic toxicity, reliable and GLP-conform studies are available for algae (P. subcapitata) and daphnids (D. magna). A 72-h NOEC of 10 mg/L based on the inhibition of algal growth rate and a 21-d NOEC of 9.7 mg/L for reproduction for daphnids were determined. According to the QSAR-based outcome of the model ECOSAR v.2.0, m-toluic acid has a very low potential for chronic toxicity to freshwater and saltwater fish since the chronic values (ChV = 10^([log (LOEC x NOEC)]/2)) for freshwater and saltwater fish are with 47.9 mg/L and 82.9 mg/L, respectively, well above the OECD limits of aquatic chronic toxicity tests. Thus, the aquatic invertebrates appear to be most sensitive, and the respective NOEC value is applied in the Chemical Safety Assessment.

Regarding aquatic microorganisms, the 3-h EC50 for the inhibition of respiration of activated sludge is above the highest test concentration of 1000 mg/L. The corresponding EC10 was estimated with 543 mg/L (nominal).

In sum, m-toluic acid has a low potential for acute and chronic aquatic toxicity.

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