Registration Dossier

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1970

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: not known
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Octyl methacrylate

Test animals

Species:
rat
Strain:
other: Alderly Park
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
6 hours/day
Frequency of treatment:
5 days/week, 3 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
saturated, 2 male and 2 female rats/dose

Control animals:
other: no data specified
Details on study design:
Post-exposure period: 24 hours

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Haematological findings:
not examined
Urinalysis findings:
not examined
Behaviour (functional findings):
not specified
Immunological findings:
not examined
Organ weight findings including organ / body weight ratios:
not examined
Neuropathological findings:
not examined
Details on results:
saturated: no signs of toxicity; no findings at autopsy, organs normal

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In a published study there were no signs of toxicity; no findings at autopsy, normal organs at a saturated atmosphere.
Executive summary:

No overt signs of toxicity were observed in a screening study in which groups of four rats (2 males and 2 females) exposed to Octyl methacrylate vapour (saturated atmosphere) for 6 hr/day, five days per week, over 3 weeks.