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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Data from secondary source (peer-reviewed handbook). The data are reported to be unpublished, original data of the author (Fasset) from the Laboratory of Industrial Medicine, Eastman Kodak Co., Rochester NY Insufficient information to determine reliability
Justification for type of information:
Read across from the 2 Ethylhexyl methacrylate category member donor substance.
REPORTING FORMAT FOR THE CATEGORY APPROACH
see attached category document
PM_Lower Alkyl (C1-C8) Methacrylates
This is a category (C1-C8 Lower Alkyl Methacrylates) with clear trends in the physicochemical properties of its members, related to molecular weight, molecular size and hydrophilicity.
There are only limited acute dermal toxicity data for the members of the category C1-C8 Lower Alkyl Methacrylates available. Guideline studies are only available for MMA and nBMA. There are reliable data for MMA and nBMA indicating that these esters are of low acute dermal toxicity. There are also two early pre-guideline studies of limited reliability available in guinea pigs for i-BMA and 2-EHMA that indicate low acute dermal toxicity and although there is no fully valid study for 2-EHMA, the upper bound of the category, there is a trend of decreasing skin absorption across the category (see section 5.1) indicating that the acute dermal toxicity of all members will be equally low. This is supported by the observation that the members are all of low acute oral toxicity.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1963

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: not known
Principles of method if other than guideline:
other
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw
Remarks on result:
other: 17620 mg/kg bw

Applicant's summary and conclusion

Conclusions:
A published LD50 >20 ml/kg bw in guinea pigs is available.
Executive summary:

A published LD50 >20 ml/kg bw in guinea pigs is available.