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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Principles of method if other than guideline:
Method: (measured): shake-flask
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 22-902-13914-28
- Purity: > 98 %
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.24
Temp.:
20 °C
pH:
ca. 6
Conclusions:
Using a valid scientific method (shake-flask method) the partition coefficient of the substance is 5.24 at 20°C.
The capability range of the method is logKow from 0 to 4. This is at the limit of the extended reliability range for this method but also consistent with a QSPR based on the lower alkyl methacrylate category.
Executive summary:

Using a valid scientific method (shake-flask method) the partition coefficient of the substance is 5.24 at 20°C.

The capability range of the method is logKow from 0 to 4. This is at the limit of the extended reliability range for this method but also consistent with a QSPR based on the lower alkyl methacrylate category.

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Description of key information

logPow 5.24 at 20°C, Jones 2002; OECD 107 (supported by lower alkyl methacrylate category QSPR)

Key value for chemical safety assessment

Log Kow (Log Pow):
5.24
at the temperature of:
20 °C

Additional information

In the key study a logPow value of 5.24 has been determined (Jones, 2002). This is at the limit of the extended reliability range for this method but also consistent with a QSPR based on the lower alkyl methacrylate category.