Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
(Q)SAR
Remarks:
Water solubility was measured experimentally for a series of alkyl-methacrylate esters from Methyl methacrylate to Decyl methacrylate. Molecular volume plotted against water solubility (on a log10scale)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
Water solubility was measured experimentally for a series of alkyl-methacrylate esters from Methyl methacrylate to Decyl methacrylate. The water solubility of alkyl-methacrylate esters decreses with increasing alkyl-chain length. Methyl methacrylate is the most soluble ester in water (measured 15.3 g/kg) at 20 °C. 2-Ethylhexyl methacrylate was the largest ester whose solubility was measured experimentally (lowest solubility with a value of 0.0078 g/kg at 20°C).
The water solubility of the alkyl-methacrylate esters decreses exponentially when plotted against molecular volume. The water solubility of both straight and branched chained members of the series showed a direct dependance on molecular volume. Molecular volume plotted against water solubility (on a log10scale) was linear. Threfore the water solubility was estimated by the linear regression analysis of data for those esters whose solubility was measured experimentally.


Qualifier:
no guideline available
Principles of method if other than guideline:
QSAR-prediction by linear regression analysis of data for those esters whose solubility was measured experimentally.
GLP compliance:
no
Type of method:
other: calculated
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 22-902-13914-28
- Purity: > 98 %
Key result
Water solubility:
5.3 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: original value: 0.0053 g/kg
Conclusions:
Using a valid scientific method the water solubility of the substance is 5.3 mg/L (original value: 0.0053 g/kg) at 20°C.
Executive summary:

Using a valid scientific method the water solubility of the substance is 5.3 mg/L (original value: 0.0053 g/kg) at 20°C.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

Using a valid scientific method the water solubility of the substance is 5.3 mg/L (original value: 0.0053 g/kg) at 20°C.

Key value for chemical safety assessment

Water solubility:
5.3 mg/L
at the temperature of:
20 °C

Additional information

Using a valid scientific method the water solubility of the substance is 5.3 mg/L (original value: 0.0053 g/kg) at 20°C.