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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

long-term toxicity to aquatic invertebrates
Type of information:
experimental study planned
according to guideline
OECD Guideline 211 (Daphnia magna Reproduction Test)

Description of key information

The water solubility of the registered substance was determined in accordance with the OECD Testing Guideline 105. The study concluded that Calcium Titanium Trioxide is poorly soluble in water (<0.3 mg/L).

As the substance is poorly soluble in water a long-term aquatic toxicity study should be considered instead of short-term studies. Therefore, short-term toxicity to aquatic invertebrates was waived in accordance with Annex VII of REACH.

During the OECD 105 it could not be excluded that nanoparticles of Calcium Titanium Trioxide will be available as a suspension in water. Therefore, due to its poorly soluble properties and to lack of certainty on suspended nanoparticles of Calcium Titanium Trioxide in water, a long term Daphnia Reproduction Test in accordance with the OECD Testing Guideline 211 is proposed (Annex IX of REACH).

Key value for chemical safety assessment

Additional information