Registration Dossier
Registration Dossier
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EC number: 234-988-1 | CAS number: 12049-50-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 12 March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on available information on the substance and experimental data on a suitable analogue.
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on available information on the substance and experimental data on a suitable analogue.
- GLP compliance:
- no
- Type of study:
- other: An assessment was performed based on available information on the substance and experimental data on a suitable analogue.
Test material
- Reference substance name:
- Calcium titanium trioxide
- EC Number:
- 234-988-1
- EC Name:
- Calcium titanium trioxide
- Cas Number:
- 12049-50-2
- Molecular formula:
- Ca.O3Ti
- IUPAC Name:
- Calcium titanium trioxide
- Reference substance name:
- Titanium dioxide
- EC Number:
- 236-675-5
- EC Name:
- Titanium dioxide
- Cas Number:
- 13463-67-7
- Molecular formula:
- O2Ti
- IUPAC Name:
- dioxotitanium
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- Silicon dioxide
- Reference substance name:
- Aluminium oxide
- EC Number:
- 215-691-6
- EC Name:
- Aluminium oxide
- Cas Number:
- 1344-28-1
- Molecular formula:
- Al2O3
- IUPAC Name:
- oxo(oxoalumanyloxy)alumane
- Reference substance name:
- Magnesium oxide
- EC Number:
- 215-171-9
- EC Name:
- Magnesium oxide
- Cas Number:
- 1309-48-4
- Molecular formula:
- MgO
- IUPAC Name:
- magnesium oxygen(-2) anion
- Reference substance name:
- Diniobium pentaoxide
- EC Number:
- 215-213-6
- EC Name:
- Diniobium pentaoxide
- Cas Number:
- 1313-96-8
- Molecular formula:
- Nb2O5
- IUPAC Name:
- diniobium pentoxide
- Test material form:
- solid: nanoform, surface-treated
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Remarks on result:
- other: Calcium Titanium Trioxide is not expected to induce skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Calcium Titanium Trioxide is not expected to induce skin sensitisation.
- Executive summary:
An assessment was performed based on available information on the substance and experimental data on a suitable analogue. It concluded that Calcium Titanium Trioxide is not expected to induce skin sensitisation.
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