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Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute dermal toxicity study of test chemical on rabbits
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, 1973
Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity of test chemical on rabbits
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Determination of acute dermal toxicity of the test chemical on rabbits
GLP compliance:
not specified
Test type:
other: Not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl formate
EC Number:
203-214-4
EC Name:
Benzyl formate
Cas Number:
104-57-4
Molecular formula:
C8H8O2
IUPAC Name:
Benzyl formate
Test material form:
liquid
Details on test material:
IUPAC name: Benzyl formate
Mol. formula: C8H8O2
Molecular Weight:136.149 gm/mol
Smiles: c1(ccccc1)COC=O
InChI: 1S/C8H8O2/c9-7-10-6-8-4-2-1-3-5-8/h1-5,7H,6H2

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
1.3-3.0 ml/kg (1300-3000 mg/kg)
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The dermal LD50 value was observed to be 2000 mg/kg when rabbits were treated with test chemical.
Executive summary:

The acute dermal toxicity study was conducted on rabbits for 14 days period. 50% mortality was observed at a dose level of 2000 mg/kg. Thus, based on the LD50 value, the test chemical cannot be classified as per the CLP regulation.