Registration Dossier

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Eye irritation study of test substance
Author:
MAK
Year:
1996
Bibliographic source:
MAK,1996
Reference Type:
other: Secondary source
Title:
Human health tier II assessment: Test chemical
Author:
NICNAS
Year:
2016
Bibliographic source:
NICNAS,2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the eye irritation potential of the test substance in rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Furfuryl alcohol
EC Number:
202-626-1
EC Name:
Furfuryl alcohol
Cas Number:
98-00-0
Molecular formula:
C5H6O2
IUPAC Name:
furfuryl alcohol

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
56 mg
Duration of treatment / exposure:
40 to 64 days
Observation period (in vivo):
40 to 64 days
Duration of post- treatment incubation (in vitro):
Not specified
Number of animals or in vitro replicates:
Not specified
Details on study design:
Not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 40 to 64 days
Reversibility:
other: Reversible within 40 to 64 days
Remarks on result:
other: Irritating
Irritant / corrosive response data:
Irritating
Other effects:
The test chemical caused inflammation, mucous secretion, and clouding of the cornea

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
An eye irritation test was conducted in rabbits for test chemical to assess the eye irritation potential.The test chemical caused inflammation, mucous secretion, and clouding of the cornea which was reversible within 40 to 64 days. Based on the ocular lesions caused by the chemical, it was considered as an eye irritant.
Executive summary:

An eye irritation test was conducted in rabbits for test chemical toassess the eye irritation potential.During the study, approx. 56 mg of test chemical was instilled into the eyes of each rabbitandanimalswere observed for ocular lesions.The test chemical caused inflammation, mucous secretion, and clouding of the cornea which was reversible within40 to 64 days.

Although the effects were reversible butbased on the observed ocular lesions it was considered as irritating to eyes of the treated rabbits.