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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
FLAME RETARDANTS IN PRINTED CIRCUIT BOARDS
Author:
US EPA
Year:
2015
Bibliographic source:
EPA Publication 744-R-15-001; August 2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To assess the ocular irritation potential of 6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide in albino rabbits according to OECD 405
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
Name of the test chemical:6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide (DOPO)
Molecular Weight: 216.175 g/mol
Molecular Formula:C12H9O2P
InChI: 1S/C12H9O2P/c13-15-12-8-4-2-6-10(12)9-5-1-3-7-11(9)14-15/h1-8,15H
Substance Type: Organic
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical:6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide (DOPO)
Molecular Weight: 216.175 g/mol
Molecular Formula:C12H9O2P
InChI: 1S/C12H9O2P/c13-15-12-8-4-2-6-10(12)9-5-1-3-7-11(9)14-15/h1-8,15H
Substance Type: Organic
Physical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
other: albino
Details on test animals or tissues and environmental conditions:
- sex: female

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.1 ml undiluted
Duration of treatment / exposure:
single exposure
Observation period (in vivo):
7 days
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
3
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
fully reversible within: 7 days
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Moderate signs of irritation which got cleared by day 7

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Moderate signs of irritation were observed which got cleared by day 7.
Since the effects were reversible by 7 days, 6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide (DOPO) can be considered not irritating to rabbit eyes.
Executive summary:

The ocular irritation potential of 6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide was assessed in albino rabbits according to OECD 405.

Neat test material (0.1 mL) was instilled in left eye of 3 female albino rabbits. Eyes were monitored for up to 7 days. Moderate signs of eye irritation that cleared in 7 days were observed among the rabbits.

Since the effects were reversible by 7 days, 6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide (DOPO) can be considered not irritating to rabbit eyes.