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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report.

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID DATASET of CAS 15206-55-0
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID DATASET, EUROPEAN COMMISSION – European Chemicals Bureau, 18–FEB–2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity test was carried out to study the effects of Methyl benzoylformate on rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material:Methyl benzoylformate
- Common name:Methyl benzoylformate
- Molecular formula :C9H8O3
- Molecular weight :164.159 g/mol
- Substance type:organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Methyl benzoylformate
- Molecular formula :C9H8O3
- Molecular weight :164.159 g/mol
- Substance type:organic
- Physical state:liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
No data available
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
10600 mg/m3
No. of animals per sex per dose:
Total : 5 animals
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 10 600 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: No mortalty was observed at concentration 10600 mg/m3
Mortality:
No mortalty was observed at concentration 10600 mg/m3
Clinical signs:
other: No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LC50 value for acute inhalation toxicity test was considered to be >10600 mg/m3 in air when rats were exposed with Methyl benzoylformate by inhalation for 4 hour.
Executive summary:

In acute inhalation toxicity study, 5 Rats were exposed to Methyl benzoylformate in the concentration of 10600 mg/ m3 inhaled as a Single dose for 4 hour.No mortality was observed at concentration 10600 mg/ m3. Therefore, LC50 value was considered to be >10600 mg/ m3 in air,when rats were exposed with Methyl benzoylformate by inhalation for 4 hour.