Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Acute oral toxicity study of test chemical in mice
Author:
E. W. Schafer et. al.
Year:
1985
Bibliographic source:
Arch. Environ. Contain. Toxicol.,1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of test chemical on deer mice (Peromyscus maniculatus).
GLP compliance:
no
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-furoic acid
EC Number:
201-803-0
EC Name:
2-furoic acid
Cas Number:
88-14-2
Molecular formula:
C5H4O3
IUPAC Name:
2-furoic acid
Test material form:
solid
Details on test material:
- Name of test material: 2-furoic acid
- IUPAC name: furan-2-carboxylic acid
- Molecular formula: C5H4O3
- Molecular weight: 112.084 g/mole
- Smiles : c1(C(O)=O)ccco1
- Inchl: 1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)
- Substance type: Organic
- Physical state: Solid powder (white)

Test animals

Species:
other: Deer mice
Strain:
other: Peromyscus maniculatus
Sex:
not specified
Details on test animals or test system and environmental conditions:
Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: No data available

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
1225 mg/kg/day
No. of animals per sex per dose:
2 to 4 animals were used per geometrically spaced dosage level
And
6 to 20 animals per experiment
Control animals:
not specified
Details on study design:
Details on study design
- Duration of observation period following administration: 3 days
- Frequency of observations and weighing:no data available
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No data available
Statistics:
Thompson (1948) and Thompson and Weil (1952)

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 225 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated deer mice at dose level 1225 mg/kg/day
Mortality:
No mortality was observed in treated deer mice at dose level 1225 mg/kg/day
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be >1225 mg/kg/day when deer mice were treated with test chemical orally via gavage over the 3-day test period without killing more than 50% of the test animals.
Executive summary:

Acute oral toxicity study was done in 2 to 4 deer mice using test chemical .No Mortality was observed at dose 1225 mg/kg/day.Hence,LD50 value was considered to be >1225 mg/kg/day when deer mice were treated with test chemical orally via gavage over the 3-day test period without killing more than 50% of the test animals.