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Density

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Reference
Endpoint:
density, other
Remarks:
Density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29-09-2017 – 29-09-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density of Test item 2-furoic acid (CAS No. 88-14-2) was determined following OECD guideline 109 and according to the method recommended in the
International Pharmacopoeia, fourth Edition, 2014.
GLP compliance:
not specified
Type of method:
other: bulk density apparatus.
Specific details on test material used for the study:
- Name of test material: 2-furoic acid
- IUPAC name: furan-2-carboxylic acid
- Molecular formula: C5H4O3
- Molecular weight: 112.084 g/mole
- Smiles : c1(C(O)=O)ccco1
- Inchl: 1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)
- Substance type: Organic
- Physical state: Solid powder (Creamish white)
Key result
Type:
pour density
Density:
0.659 g/cm³
Temp.:
26.2 °C
Remarks on result:
other: at 969.8 hPa pressure
Key result
Type:
tap density
Density:
0.773 g/cm³
Temp.:
26.2 °C
Remarks on result:
other: at 969.8 hPa pressure

TEST ITEM DESCRIPTION AND RESULTS

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1st

Reading

2nd Reading

 

 

Method

Test methods: Pour density and tapped density of powders recommended inThe International

Pharmacopoeia, Fourth Edition, 2014

 

 

Principle of method

Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder.

Tap Density:It is the difference between the volume of test item

measured before & after tapping in the graduated glass cylinder.

 

 

Test temperature (°C)

-

26.5°C

26.0°C

Atmospheric

pressure (in hPa)

-

970.7

969.0

Weight of test

item(m)

 

 

20.100

20.100

Volume of measuring cylinder; readability in g

 

50ml; 1 ml

50 ml; 1 ml

Volume of test item

without tapping (V)

 

30

31

Volume of test item

after tapping ( V1)

After 10 tapping

28

27

 

After 50 tapping

27

26

 

After 100 tapping

26

26

 

After 250 tapping

26

26

 

After 500 tapping

-

-

 

After 750 tapping

-

-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

 

 

By Pour Density and Tapped Density Method:

 

 

Parameters

 

Details

Calculated values

Average

Density

1st

Calculation

2nd

Calculation

Pour Density of test Item (g/cm³)

= m / V

 

0.6700

0.6483

0.6591

Tap density of test Item (g/cm³)

= m / V1

 

0.7730

0.7730

0.7730

Conclusions:
The mean pour density and tapped density of 2-furoic acid (CAS No. 88-14-2) was determined to be 0.6591 g/cm³ and 0.7730 g/cm³at 26.2°C and 969.8 hPa.
Executive summary:

The density of test item 2-furoic acid (CAS No. 88-14-2) was determined following OECD Guideline 109 and according to theTest methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density

apparatus. The mean pour density and tapped density of test item was determined to be 0.6591 g/cm³ and 0.7730 g/cm³ at 26.2°C and 969.8 hPa.

Description of key information

The mean pour density and tapped density of 2-furoic acid (CAS No. 88-14-2) was determined to be 0.6591 g/cm³ and 0.7730 g/cm³at 26.2°C and 969.8 hPa.

Key value for chemical safety assessment

Relative density at 20C:
0.773

Additional information

The density of test item 2-furoic acid (CAS No. 88-14-2) was determined following OECD Guideline 109 and according to theTest methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density

apparatus. The mean pour density and tapped density of test item was determined to be 0.6591 g/cm³ and 0.7730 g/cm³ at 26.2°C and 969.8 hPa.