Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

FR-370 is not expected to accumulate significantly within tissues of aquatic organisms, based on the low water solubility and a Bioconcentration factor (BCF) of 200. This result is further supported by the ADME study in rats that show only minor absorption and retention of FR-370 in tissues (<2%), indicating virtually negligible uptake of the substance.