Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 4-methylbenzonitrile (104-85-8) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 4-methylbenzonitrile (104-85-8) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of 4-methylbenzonitrile (104-85-8) on rats.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (IUPAC name): 4-methylbenzonitrile
- Common name: p-Tolunitrile
- Molecular formula: C8H7N
- Molecular weight: 117.15 g/mol
- Smiles notation: c1(ccc(C)cc1)C#N
- InChl: 1S/C8H7N/c1-7-2-4-8(6-9)5-3-7/h2-5H,1H3
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):p-Tolunitrile
- Molecular formula :C8H7N
- Molecular weight :117.15 g/mol
- Substance type:organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3800 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 800 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed at dose 3800 mg/kg bw
Mortality:
50% mortality was observed at dose 3800 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 3800 mg/kg bw ,when rats were treated with 4-methylbenzonitrile (104-85-8) orally
Executive summary:

Acute oral toxicity study was done in rats using test material 4-methylbenzonitrile(104-85-8).50% Mortality was observed at dose 3800 mg/kg bw. Hence,LD50 value was considered to be 3800 mg/kg bw,when rats were treated with 4-methylbenzonitrile(104-85-8)orally.