Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (IUPAC name): 1,3-Benzenedicarbonitrile
- Common name: 1,3-Dicyanobenzene
- Molecular formula: C8H4N2
- Molecular weight: 128.134 g/mol
- Smiles notation: c1c(cccc1C#N)C#N
- InChl: 1S/C8H4N2/c9-5-7-2-1-3-8(4-7)6-10/h1-4H
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):1,3-Dicyanobenzene
- Molecular formula :C8H4N2
- Molecular weight :128.134 g/mol
- Substance type:organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed at dose 2000 mg/kg bw
Mortality:
No mortality was observed at dose 2000 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with 1,3-Benzenedicarbonitrile (626-17-5) by dermal application.
Executive summary:

In acute dermal toxicity study,rabbits were treated with 1,3-Benzenedicarbonitrile (626-17-5) in the concentration of 2000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 2000 mg/kg bw.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with 1,3-Benzenedicarbonitrile(626-17-5)by dermal application.