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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authorative database

Data source

Reference
Reference Type:
other: Authorative database
Title:
Eye irritation potential of Benzonitrile
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Benzonitrile ) 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate eye irritation potential of Benzonitrile on rabbits.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
IUPAC name: Benzonitrile
Molecular formula :C7H5N
Molecular weight :103.123 g/mol
Substance type: organic
Physical state: Colorless liquid
InChI :1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H
Smiles:c1(ccccc1)C#N



Specific details on test material used for the study:
IUPAC name: Benzonitrile
Molecular formula :C7H5N
Molecular weight :103.123 g/mol
Substance type: organic
Physical state: Colorless liquid
InChI :1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H
Smiles:c1(ccccc1)C#N



Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: Not specified
Reversibility:
fully reversible within: 10 days
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Reddening of the conjunctiva, no irritation to the cornea and iris, minor vascular injection, apparently reversible after 10 days

Applicant's summary and conclusion

Interpretation of results:
Category 2A (irritating to eyes) based on GHS criteria
Conclusions:
Benzonitrile when administrated on rabbit eye produced reddening of the conjunctiva, no irritation to the cornea and iris, minor vascular injection. These reactions were reversible after 10 days. Based on the ocular reactions Benzonitrile was considered to be slight eye irritant.
Executive summary:

Benzonitrile was used as a test material to evaluate its ocular irritation potential on rabbits.

Benzonitrile when administrated on rabbit eye producedreddening of the conjunctiva, no irritation to the cornea and iris, minor vascular injection. These reactions were reversible after 10 days. Based on the ocular reactions Benzonitrile was considered to be slight eye irritant.