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EC number: 248-890-1 | CAS number: 28188-41-2
Half life of hydrolysis of test chemical 3-(bromomethyl)benzonitrile was estimated by using HYDROWIN Program (v2.00) of EPI suite. The half life of hydrolysis of test chemical 3-(bromomethyl)benzonitrile was estimated to be 1.32 hrs. Based on this half life value it is concluded that test chemical 3-(bromomethyl)benzonitrile is rapidly hydrolysable.
Predicted data study for target chemical 3-(bromomethyl)benzonitrile (CAS no.28188-41-2) and experimental study for its structurally similar read across chemical is summarized below.
In a predicted data study the half life of hydrolysis of test chemical 3-(bromomethyl)benzonitrile was estimated by using HYDROWIN Program (v2.00) of EPI suite. The half life of hydrolysis of test chemical 3-(bromomethyl)benzonitrile was estimated to be 1.32 hrs.
Another supporting experimental study was done from authoritative database (HSDB, 2017) in this study the hydrolysis rate constant of structurally similar read across chemical 1-(bromomethyl)-3-methylbenzene (CAS no. 630-13-3) obtained was 0.000056 /sec and hydrolysis half life is 3.4 hrs at 20 oC for O isomer of read across chemical. Another hydrolysis rate constant value of read across chemical determined was 0.00256/sec and half life of hydrolysis is 4.3 mins at 25 oC for p isomer. Based on the half life of hydrolysis value at 25 oC it is concluded that this read across chemical is rapidly hydrolysabe.
On the basis of half life value determined by both the studies it is concluded that test chemical 3-(bromomethyl)benzonitrile is expected to be rapidly hydrolysable.
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