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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authorative data base

Data source

Reference
Reference Type:
other: Authorative database
Title:
Eye irritation potential of Benzonitrile
Author:
IFA (GESTIS)
Year:
2017
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Benzonitrile ) 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate skin irritation potential of Benzonitrile on rabbits.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
IUPAC name: Benzonitrile
Molecular formula :C7H5N
Molecular weight :103.123 g/mol
Substance type: organic
Physical state: Colorless liquid
InChI :1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H
Smiles:c1(ccccc1)C#N



Specific details on test material used for the study:
IUPAC name: Benzonitrile
Molecular formula :C7H5N
Molecular weight :103.123 g/mol
Substance type: organic
Physical state: Colorless liquid
InChI :1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H
Smiles:c1(ccccc1)C#N


Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Intact or scarified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
24 hrs
Observation period:
24 hrs
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Slight irritation reactions were observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Benzonitrile when applied on rabbit skin in undiluted concentration for 24 hrs caused slight irritation . Hence, Benzonitrile was considered to be skin irritant
Executive summary:

Benzonitrile was used as a test material to evaluate skin irritation potential on rabbits.

The test material was applied on the intact or scarified rabbit skin in undiluted concentration under occlusion for 24 hrs. Slight irritation reactions were observed. Hence, Benzonitrile was considered to be skin irritant.