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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 FEB 2010 to 9 NOV 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted in accordance with current testing guidelines and GLP-compliant.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Principles of method if other than guideline:
A modified shake flask method was used due to the miscibility issues during the preliminary test.
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
> 3.2 - < 109 g/L
Conc. based on:
test mat.
Temp.:
30 °C
pH:
> 1.1 - < 2
Details on results:
MK92K contains components of differing solubility's with some that are highly water soluble and others that are insoluble in water.

Solubility Data in Double Distilled Water

Empower sequence

Time at 30°C (h)

pH

Water solubility (g/L) for the different components

1

2

3

4

5

6

7

8

Wat sol 1/1

72

1.15

121.337198

4.319104

9.253571

57.816957

17.364575

24.838698

3.083244

7.379179

Wat sol 1/2

118.574615

4.604040

9.702959

57.231721

17.408307

23.399703

2.818549

6.130783

Wat sol 2/1

1.17

113.414097

4.616720

9.698897

59.470359

17.690547

23.697769

3.357619

4.467738

Wat sol 2/2

111.103757

4.591120

9.755235

59.707105

17.573097

24.461391

3.189871

4.115053

Wat sol 3/1

48

1.24

111.664698

4.544294

9.667858

57.153139

17.430543

22.769146

3.191545

7.278253

Wat sol 3/2

108.863743

4.531065

9.235040

57.386382

16.940904

22.498112

2.956469

7.840833

Wat sol 4/1

1.22

103.017131

4.447034

9.453493

58.247427

17.220243

22.975569

4.351804

6.008563

Wat sol 4/2

103.816730

4.514593

9.270085

58.354612

17.746479

23.084906

3.063403

6.019195

Wat sol 5/1

24

1.26

105.281349

4.508196

9.801496

58.251510

17.053431

23.070927

3.099800

4.723000

Wat sol 5/2

102.137493

4.422346

9.754621

58.134522

17.391539

22.924026

3.173515

5.269974

Wat sol 6/1

1.24

104.817783

4.591908

9.919605

60.173027

17.802809

23.865584

3.074666

7.163433

Wat sol 6/2

107.140057

4.495398

9.813308

59.613141

18.082690

23.856611

2.717002

5.637709

Mean (g/L)

 

 

 

 

109.3

4.515

9.611

58.46

17.48

23.45

3.173

6.003

Std Dev

 

 

 

 

6.169

0.08692

0.2419

1.037

0.3247

0.7072

0.4090

1.224

RSD (%)

 

 

 

 

5.65

1.925

2.517

1.774

1.858

3.015

12.889

20.398

Conclusions:
Interpretation of results (migrated information): other: MK92K contains components of differing solubility's with some that are highly water soluble and others that are insoluble and others that are insoluble in water.
MK92K contains components of differing solubility's with some that are highly water soluble and others that are insoluble in water. Mean solubility values ranged from ca 3.2 to 109.3 g/L, with one component proving insoluble in water.
Executive summary:

The calibration lines were established linearly with no weighting. The resultant pH was 1.2.

The temperature of the 30°C water bath incubation bath was constant at a temperature of 30.1°C over the test period. The temperature of the 20°C incubation bath ranged between 30.0[1] and 19.7°C with an average temperature of 19.8°C over the test period.

The data broadly support the results obtained from the partition coefficient evaluation that MK92K contains components of differing solubilities with some that are highly water soluble and others that are insoluble in water. Mean solubility values ranged from ca 3.2 to 109.3 g/L, with one component (peak 9) proving insoluble in water.


[1]     The water bath was outside of the specified limits for ca 37 minutes whilst the water bath cooled from 30°C.

Description of key information

MK92K contains components of differing solubility's with some that are highly water soluble and others that are insoluble in water. Mean solubility values ranged from ca 3.2 to 109.3 g/L, with one component proving insoluble in water.

A figure of 100 g/l is used for Chesar

Key value for chemical safety assessment

Water solubility:
100 g/L
at the temperature of:
30 °C

Additional information

The water solubility of MK92K was determined according to OECD Guideline 105 (water solubility) and EU Method A.6 (water solubility). A modified shake flask method was used due to the miscibility issues during the preliminary test.

It is acknowledged that due to the complex nature of the test substance the cited test guidelines are not directly applicable as they are usually used for pure test substances. However, the use of a miscibility test for the test substance is less relevant due to the varying water solubilities expected from the composition and so it was felt that the use of the guidelines cited above was more appropriate. Results obtained from the test should be regarded as indicative rather than fully quantitative.