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EC number: 200-837-3 | CAS number: 75-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-07-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restrictions because it was an acceptable, well-documented study report which meets basic scientific principles.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- The guideline followed was not reported but the methods used are deemed appropriate as utilized in the report.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Ethanethiol
- EC Number:
- 200-837-3
- EC Name:
- Ethanethiol
- Cas Number:
- 75-08-1
- Molecular formula:
- C2H6S
- IUPAC Name:
- ethanethiol
- Details on test material:
- - Name of test material (as cited in study report): ethyl mercaptan (ethanethiol)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: outbred SPF mice (CD-1, COBS)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: Young adults
- Weight at study initiation: 20-25 grams
- Housing: Stainless-steel wire-mesh cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.11
- Humidity (%): 40-60%
- Air changes (per hr): No data reported
- Photoperiod (hrs dark / hrs light): 12 hrs/ 12 hrs
Administration / exposure
- Route of administration:
- other: Inhalation, head only
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure is one minute, followed by ten minutes in room air, followed by another one minute exposure.
- Post exposure period:
- The animals are observed in real time during the exposures and for at least five minutes or until recovery from exposure.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.93 mg/L (56.75 ppm)
Basis:
- No. of animals per sex per dose:
- 4
- Control animals:
- no
Results and discussion
- Details on results:
- No effects of exposure to ethyl mercaptan at 1.93 mg/L were observed.
Applicant's summary and conclusion
- Conclusions:
- Based on the results the authors concluded that the test material is not an irritant when 1.93 mg/L is inhaled by mice (Pence, 1983).
- Executive summary:
In a respiratory irritation tract study (Pence, 1983), 4 male outbred SPF mice were exposed via head only inhalation to 1.93 milligram per liter (56.75 ppm) of ethanethiol for two periods of one minute exposures separated by a ten minute exposure to room air. Animals were then observed for five minutes or until the respiratory rate returned to pre-exposure rates.
The test material was applied as a vapor in a head only exposure chamber attached to a plethysmograph. Only three mice were exposed because one mouse was reported to have died prior to exposure. None of the three mice demonstrated changes in respiratory rate during either one minute exposures to 1.93 mg/L ethanethiol. Based on the results the authors concluded that the test material is not an irritant when 1.93 mg/L is inhaled by mice. Compound-induced corrosion was not reported.
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