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EC number: 200-837-3 | CAS number: 75-08-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 276.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No repeat dose toxicity data were available for ethanethiol. However, a key read across study (Ulrich, 1982) was available for butane-1-thiol. Both butane-1-thol and ethanethiol are members of the C2-C4 aliphatic thiols category. In this 90-day inhalation study, the repeated dose toxicity of butane-1-thiol was investigated in Sprague-Dawley rats. The NOAEC was identified to be 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested.
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA default
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 5
- Justification:
- ECHA default (workers)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 159.5 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No dermal repeat dose toxicity data were available for ethanethiol. One oral read across study (MHLW, 2006; Klimisch score = 2) of 2 -methylpropane-2-thiol has been performed but not used in the derivation of this DNEL because the exposure period was subacute. Therefore, read across inhalation data (Ulrich, 1982) from butane-1-thiol was used by performing a route-to-route extrapolation. The NOAEC used was 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested..
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 5
- Justification:
- ECHA default (workers)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Long-term exposure – Systemic effects:
1) Dermal DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
Step 2) Modification of starting point |
Conversion for units: 0.55 mg/L x 1000 = 550 mg/m3 |
Correction of rat inhalation NOAEC to rat dermal NOAEL – correction for respiratory volume and for difference in absorption rates |
NOAELrat: 159.5 mg/kg bw/day (= 550 x 0.29* x 1) Assumption: Based on ECHA guidance (Chapter R.8) no default factor was applied for differences in absorption in rats and humans and therefore absorption was assumed to be 100% via the dermal and inhalation route *Respiration rate in rats for 6 hour exposure |
Step 3) Assessment factors |
ECHA assessment factors used |
Interspecies (allometric scaling) |
4 (rat) |
Interspecies |
2.5 (for systemic effects) |
Intraspecies |
5 (for worker population) |
Exposure duration |
2 (for sub-chronic to chronic) |
Dose response |
1 |
Quality of database |
1 |
Total Assessment Factors |
100 |
Worker DNELlong-term for dermal route -Systemic |
1.6(= 159.5 x 1/(4 x 2.5 x 5 x 2 x 1 x 1)) |
2) Inhalation DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
| Step 2) Modification of starting point | Conversion for units:0.55mg/L x 1000 = 550 mg/m3 |
| Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default worker exposure (8 hrs/day, 5 days/ week) |
| Correction for activity driven differences of respiratory volumes in workers compared to workers in rest | 6.7 m3/10 m3Corrected NOAEC = 276.4 mg/m3(= 550 x 6/8 x 6.7/10) |
| Step 3) Assessment factors | ECHA assessment factors used |
| Interspecies | 2.5 (for systemic effects) |
| Intraspecies | 5 (for workers) |
| Exposure duration | 2 (for sub-chronic to chronic) |
| Dose response | 1 |
| Quality of database | 1 |
| Total Assessment Factors | 25 |
| Worker DNELlong-term for inhalation route -Systemic | 11 mg/m3 (= 276.4 x 1/(2.5 x 5 x 2 x 1 x 1)) |
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.96 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 98.2 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No repeat dose toxicity data were available for ethanethiol. However, a key read across study (Ulrich, 1982) was available for butane-1-thiol, a structural analogue of ethanethiol. In this 90-day inhalation study, the repeated dose toxicity of butane-1-thiol was investigated in Sprague-Dawley rats. The NOAEC was identified to be 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested..
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA default
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 10
- Justification:
- ECHA default (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 159.5 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No oral repeat dose toxicity data was available for ethanethiol. One key read across study (MHLW, 2006; Klimisch score = 1) of 2-methylpropane-2-thiol has been performed but not used in the derivation of this DNEL because it was a subacute study that only tested up to a maximum dose of 200 mg/kg bw/day and no adverse effects were recorded. Therefore in the absence of suitable oral data, key read across inhalation data (Ulrich, 1992) from butane-1-thiol (structural analogue) was used by performing a route-to-route extrapolation. The NOAEC used was 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested..
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 10
- Justification:
- ECHA default (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Long-term exposure – Systemic effects:
2) Inhalation DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
| Step 2) Modification of starting point | Conversion for units: 0.55 mg/L x 1000 = 550 mg/m3 |
| Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default general population exposure (24 hrs/day, 7 days/ week) Corrected NOAEC = 98.2 mg/m3(= 550 x 6/24 x 5/7) |
| Step 3) Assessment factors | ECHA assessment factors used |
| Interspecies | 2.5 (for systemic effects) |
| Intraspecies | 10 (for general population) |
| Exposure duration | 2 (for sub-chronic to chronic) |
| Dose response | 1 |
| Quality of database | 1 |
| Total Assessment Factors | 50 |
| General Population DNELlong-term for inhalation route -Systemic | 1.96 mg/m3 (= 98.2 x 1/(2.5 x 10 x 2 x 1 x 1)) |
3) Oral DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
| Step 2) Modification of starting point | Conversion for units: 0.55 mg/L x 1000 = 550 mg/m3 |
| Correction of rat inhalation NOAEC to rat oral NOAEL – correction for respiratory volume and for difference in absorption rates | NOAELrat:159.5 mg/kg bw/day (= 550 x 0.29 x 1) Assumption: Based on ECHA guidance (Chapter R.8) no default factor was applied for differences in absorption in rats and humans and therefore absorption was assumed to be 100% via the oral and inhalation route |
| Step 3) Assessment factors | ECHA assessment factors used |
| Interspecies (allometric scaling) | 4 (rat) |
| Interspecies | 2.5 (for systemic effects) |
| Intraspecies | 10 (for general population) |
| Exposure duration | 2 (for sub-chronic to chronic) |
| Dose response | 1 |
| Quality of database | 1 |
| Total Assessment Factors | 200 |
| General Population DNELlong-term for oral route -Systemic | 0.8 mg/kg bw/day (= 159.5 x 1/(4 x 2.5 x 10 x 2 x 1 x 1)) |
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