Registration Dossier
Registration Dossier
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EC number: 200-837-3 | CAS number: 75-08-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Industrial Standards for Substances Emitting Strong Odors.
- Author:
- Blinova, E.A.
- Year:
- 1 965
- Bibliographic source:
- Gig. i Sanit. 30(1): 18 - 22
Materials and methods
- Endpoint addressed:
- respiratory irritation
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethanethiol
- EC Number:
- 200-837-3
- EC Name:
- Ethanethiol
- Cas Number:
- 75-08-1
- Molecular formula:
- C2H6S
- IUPAC Name:
- ethanethiol
Constituent 1
Method
- Ethical approval:
- not specified
- Exposure assessment:
- not specified
- Details on exposure:
- TYPE OF EXPOSURE: Inhalation - whole body
EXPOSURE LEVELS: 10 mg/m3 (ppm) and 1 mg/m3 (0.5 ppm)
EXPOSURE PERIOD: 3 hours daily for 5 to 10 days
Results and discussion
- Results:
- Human volunteers exposed to ethanethiol at 10 mg/m3 (4 ppm) 3 hours daily during 5 to 10 days produced effects that included a rise in the olfactory threshold and altered taste reaction to bitter and sweet substances; periodic nausea; irritation of mucous membranes of the lips, mouth, and nose; and a sensation of fatigue. Exposure at 1 mg/m3 (0.5 ppm) produced no unpleasant symptoms.
Applicant's summary and conclusion
- Conclusions:
- Human volunteers exposed to ethanethiol at 10 mg/m3 (4 ppm) 3 hours daily during 5 to 10 days produced effects that included a rise in the olfactory threshold and altered taste reaction to bitter and sweet substances; periodic nausea; irritation of mucous membranes of the lips, mouth, and nose; and a sensation of fatigue. Exposure at 1 mg/m3 (0.5 ppm) produced no unpleasant symptoms.
- Executive summary:
Human volunteers exposed to ethanethiol at 10 mg/m3 (4 ppm) 3 hours daily during 5 to 10 days produced effects that included a rise in the olfactory threshold and altered taste reaction to bitter and sweet substances; periodic nausea; irritation of mucous membranes of the lips, mouth, and nose; and a sensation of fatigue. Exposure at 1 mg/m3 (0.5 ppm) produced no unpleasant symptoms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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