Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Industrial Standards for Substances Emitting Strong Odors.
Author:
Blinova, E.A.
Year:
1965
Bibliographic source:
Gig. i Sanit. 30(1): 18 - 22

Materials and methods

Endpoint addressed:
respiratory irritation
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Ethical approval:
not specified
Exposure assessment:
not specified
Details on exposure:
TYPE OF EXPOSURE: Inhalation - whole body

EXPOSURE LEVELS: 10 mg/m3 (ppm) and 1 mg/m3 (0.5 ppm)

EXPOSURE PERIOD: 3 hours daily for 5 to 10 days

Results and discussion

Results:
Human volunteers exposed to ethanethiol at 10 mg/m3 (4 ppm) 3 hours daily during 5 to 10 days produced effects that included a rise in the olfactory threshold and altered taste reaction to bitter and sweet substances; periodic nausea; irritation of mucous membranes of the lips, mouth, and nose; and a sensation of fatigue. Exposure at 1 mg/m3 (0.5 ppm) produced no unpleasant symptoms.

Applicant's summary and conclusion

Conclusions:
Human volunteers exposed to ethanethiol at 10 mg/m3 (4 ppm) 3 hours daily during 5 to 10 days produced effects that included a rise in the olfactory threshold and altered taste reaction to bitter and sweet substances; periodic nausea; irritation of mucous membranes of the lips, mouth, and nose; and a sensation of fatigue. Exposure at 1 mg/m3 (0.5 ppm) produced no unpleasant symptoms.
Executive summary:

Human volunteers exposed to ethanethiol at 10 mg/m3 (4 ppm) 3 hours daily during 5 to 10 days produced effects that included a rise in the olfactory threshold and altered taste reaction to bitter and sweet substances; periodic nausea; irritation of mucous membranes of the lips, mouth, and nose; and a sensation of fatigue. Exposure at 1 mg/m3 (0.5 ppm) produced no unpleasant symptoms.