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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Über die Wirkungen von Tetralin, 5-Tetralol und 5-Tetralon auf Körpertemperatur und Stoffwechsel
Author:
Kanitz HR, Lohmeyer A and Scholz J
Year:
1935
Bibliographic source:
Arch. Hyg. Bak. 113, 234-244

Materials and methods

Principles of method if other than guideline:
See Test Conditions
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Tetralin
IUPAC Name:
Tetralin
Constituent 2
Chemical structure
Reference substance name:
1,2,3,4-tetrahydronaphthalene
EC Number:
204-340-2
EC Name:
1,2,3,4-tetrahydronaphthalene
Cas Number:
119-64-2
Molecular formula:
C10H12
IUPAC Name:
1,2,3,4-tetrahydronaphthalene
Details on test material:
purified 1,2,3,4-Tetrahydronaphthalene

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ORGANISMS
- Weight at study initiation: range 170-270 g (adults)
- Number of animals: 2 per route of application, total 6

Administration / exposure

Route of administration:
other: oral feed / s.c. / i.v.
Details on exposure:
ADMINISTRATION / EXPOSURE 
- Duration of test/exposure:    Days 1, 6, 12-22
- Type of exposure: oral, s.c., or i.v.
Duration of treatment / exposure:
1+1+11 days (no treatment on days 2-5 and 7-11)
Frequency of treatment:
13 times
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 ml/animal and application
Control animals:
other: no data specified
Details on study design:
Post-exposure period: 6 days

Examinations

Observations and examinations performed and frequency:
CLINICAL OBSERVATIONS AND FREQUENCY: 
- Body weight: daily
- Food consumption: daily
- Urinalysis: daily 24 hour-samples analyzed for nitrogen, carbon, and  chemical oxygen demand
Sacrifice and pathology:
ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC): 
- Macroscopic: liver, kidney, others not listed
- Microscopic: liver, kidney

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
effects observed, treatment-related
Food consumption and compound intake (if feeding study):
effects observed, treatment-related
Description (incidence and severity):
reduced feed intake
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
effects observed, treatment-related
Details on results:
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL: 
- Mortality and time to death: No mortalities
- Food/water consumption: Decreased (not quantified)
- Urinalysis:    Variations in quantity;    Nitrogen concentration approximately constant, increased upon repeated  exposure indicating increase of 
protein conversion rate;    Carbon  content and COD significantly increased;    No proteins found;    Dark discoloration only after repeated 
application or after application  of test substance not purified from hydroperoxides.
- Gross pathology: Yellow stained, slightly swelled kidneys and livers
- Histopathology: No findings in kidneys and livers

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion