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EC number: 204-340-2
CAS number: 119-64-2
RESULTS OF TEST
- Sensitization reaction: 0/20 (none of the animals showed a positive reaction
at 24 and 48 hrs)
- Irritation: No reaction was caused by the corn oil patch.
- Body weights: No treatment-related effects were observed.
- Clinical signs: After intracutaneous application, the places of injections
showed intense erythema and edema as well as necroses in case of
with Freund's Complete Adjuvant (FCA), distinct erythema and edema
of treatment with 20 % test substance, and slight erythema in case of
treatment with corn oil.
- After removal of the first patch (i.e. 2nd induction treatment), all animals
treated with FCA displayed at the locations of injection moderate to severe
inflammation, part of them bleeding and showing crusts 24 hours after patch
In a dermal sensitisation study according to Magnusson and Kligman a
group of twenty female guinea pigs received tetrahydronaphthalene as 20%
dilution in corn oil by the intracutaneous route followed by dermal
application of the undiluted test item in the induction phase.
Challenge was with undiluted tetrahydronaphthalene, no skin
sensitisation was observed.
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