Isooctyl acrylate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No description of GLP compliance is available

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: U.S. Federal Hazardous Substances Labeling Act, CFR 1500.41 Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, September 1973

Deviations:

not specified

Principles of method if other than guideline:

U.S. Federal Hazardous Substances Labeling Act, CFR 1500.41 Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, September 1973

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

T-1746IE

IUPAC Name:

T-1746IE

Constituent 2

Reference substance name:

Isooctyl acrylate

EC Number:

249-707-8

EC Name:

Isooctyl acrylate

Cas Number:

29590-42-9

Molecular formula:

C11H20O2

IUPAC Name:

2-methylheptyl prop-2-enoate

Details on test material:

- Name of test material (as cited in study report: T-1746IE
- Physical state: Liquid

Test animals

Species:

rabbit

Strain:

other: Albino

Test system

Type of coverage:

semiocclusive

Preparation of test site:

other: intact and abraded

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml

Duration of treatment / exposure:

24hours

Observation period:

Readings were made at 24 and 72 hours

Number of animals:

6

Details on study design:

TEST SITE
- Type of wrap if used: Gauze patches were placed over the treated areas and an impervious material was wrapped snugly around the trunks of the animals to hold the patches in place.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not washed

SCORING SYSTEM: Draize Scoring; 0-4 for erythema and eschar formation, and 0-4 for edema formation. Scores were determined at 24 and 72 hours. Scores were totaled and divided by 4 to determine the primary irritation score (maximum 8.0)

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

other: PII Calculation

Time point:

other: 24/72 h

Score:

ca. 1

Irritant / corrosive response data:

Not a primary dermal irritant

Any other information on results incl. tables

Scores of 1 were obtained for all animals at 24 and 72 hours for erythema and eschar formation for both intact and abraded skin. Scores of 0 were obtained for all animals at 24 and 72 hours for edema formation for both intact and abraded skin. The primary irritation score was calculated to be 1.0/8.0

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: US CPSC / US OSHA

Conclusions:

The test material was not a primary dermal irritant based on the test conditions.

Executive summary:

Undiluted test material (0.5 ml) was applied to intact and abraded skin of 6 albino rabbits. Gauze patches and impervious dressing were placed over the test sites for 24 hours. Skin was examined at 24 and 72 hours to determine irritation scores. The Draize method of scoring was used. Scores of 1 were obtained for all animals at 24 and 72 hours for erythema and eschar formation for both intact and abraded skin. Scores of 0 were obtained for all animals at 24 and 72 hours for edema formation for both intact and abraded skin. The primary irritation score was calculated to be 1.0/8.0. The test material was not a primary dermal irritant based on the test conditions.