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EC number: 249-707-8
CAS number: 29590-42-9
48 hour EC50 (immobilization) to Daphnia magna: 0.40 mg/L (OECD Guideline 202).
short-term toxicity of the substance, IOA (CAS# 29590-42-9), to Daphnia
magna was assessed in two studies. In
the key study, which was conducted under static, closed conditions, the
48-hour EC50 was reported as 0.40 mg/L based on mean measured
concentrations. The supporting study also utilized static, closed
conditions, and the 48-hour EC50 was 1.40 mg/L based on initial measured
reasons detailed below, the 48-hr EC50 for Daphnia magna has been
determined to be 0.40 mg/L.
determination of the acute toxicity to Daphnia magna in the key
study was based on OECD Guideline 202 utilized measured concentrations
and was GLP-compliant. Daphnid
neonates (< 24-hours old) were exposed to nominal concentrations of 0,
0.5, 1.0, 2.0, 4.0 and 8.0 mg/L, corresponding to mean measured
concentrations of <0.04, 0.24, 0.53, 1.21, 2.78, and 7.40 mg/L for
48-hour EC50 was 0.40 mg/L based on mean measured concentrations. This
study is classified as acceptable and satisfies the guideline
requirements for an OECD Guideline 202, acute toxicity study with
freshwater invertebrates. It
has been given a reliability score of 2 (reliable with restrictions)
because of sharp reduction in measured test substance concentrations
(ca. 50%) over the exposure period and low recovery (77%) from the test
supporting study, while also based on OECD 202, was not GLP compliant. In
addition, a final report on the chemical analyses was not available,
only summary values. It
has been determined that the notified substance is readily biodegradable
and volatile, and difficulties have been noted with maintaining a
constant concentration in water during ecotoxicological studies such as
the aforementioned key study. There
was an approximate loss of 45% of the test substance in the test
solutions of the supporting study by 48 hours. The
EC50, 1.40 mg/L was calculated based on initial concentrations. Because
the analytical report is not available, it is felt it is not warranted
to recalculate the EC50 based on mean measured concentrations. The
EC50 reduced by 45% is approximately 0.6 mg/L. Therefore,
the results of this study are considered supportive of the key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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