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EC number: 249-707-8 | CAS number: 29590-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No description of GLP compliance is availabile.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Federal Hazardous Substances Labeling Act, CFR 1500.42 Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, September 1973
- Deviations:
- no
- Principles of method if other than guideline:
- U.S. Federal Hazardous Substances Labeling Act, CFR 1500.42 Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, September 1973
- GLP compliance:
- no
Test material
- Reference substance name:
- Isooctyl acrylate
- EC Number:
- 249-707-8
- EC Name:
- Isooctyl acrylate
- Cas Number:
- 29590-42-9
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 2-methylheptyl prop-2-enoate
- Reference substance name:
- T-1746IE
- IUPAC Name:
- T-1746IE
- Details on test material:
- - Name of test material (as cited in study report: T-1746IE
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Young adults
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- 0.1 ml of the test material was instilled into the right eyes and was not washed from the eyes
- Observation period (in vivo):
- 1, 24, 48, 72 hours and 5 and 7 days
- Number of animals or in vitro replicates:
- 6 animals per dose
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No washing
- Time after start of exposure: First observation at 1 hour after exposure
SCORING SYSTEM: Draize scoring
TOOL USED TO ASSESS SCORE: Not described
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: The mean primary irritation scores at examinations: 1h: 1/8, 24h: 0/8, 48h: 0/8, 72h: 0/8, 7d: 0/8
- Remarks:
- All animals (6/6) exhibited discharge at 1-hour (scores of 1), and 4/6 animals exhibited mild chemosis (scores of 1) at 1 hour. No irritation was observed at any other time point.
- Irritant / corrosive response data:
- Test material was determined not to be a primary ocular irritant.
Any other information on results incl. tables
72 -hours score : 0.0 -8.0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US OSHA
- Conclusions:
- The test material was not a primary ocular irritant based on test conditions.
- Executive summary:
Undiluted test material (0.1 ml) was instilled into the right eyes of six young adult albino rabbits. The test material was not washed from the eyes. Contralateral eyes were used as controls. Eyes were examined at 1, 24, 48, 72 hours and 5 and 7 days and scored (Draize method). The mean primary irritation scores at examinations: 1-hour (1.0/8.0); 24 hours (0.0/8.0); 48 hours (0.0/8.0); 72 hours (0.0/8.0); 5 days (0.0/8.0); and 7 days (0.0/8.0). At 1-hour, all animals exhibited a slight discharge and four of the animals had slight chemosis. No evidence of irritation was noted at any other examination time. The test material was concluded not to be a primary ocular irritant.
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