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EC number: 249-707-8
CAS number: 29590-42-9
The skin sensitization potential
of two samples of CASRN 29590-42-9 (MTDID 7819CE and MTDID 7819LS) was
evaluated in a local lymph node assay per OECD 429 and OECD GLP (1997).
Based on the results of a pre-screen test, test article concentrations
of 25, 50, and 100% were tested in the main test (vehicle: acetone:olive
oil 4:1), along with a concurrent positive control (25%
alpha-hexylcinnamaldehyde in acetone:olive oil). The dorsal surface of
both ears of female mice (5/group) were topically treated (25 uL/ear)
with the appropriate test article concentration (0, 25, 50, or 100%), at
the same time on Days 1, 2, and 3. Three days after the final exposure,
all animals were injected with 3H-methyl thymidine and after five hours
the draining (auricular) lymph nodes were excised and pooled for each
animal. After precipitating the DNA of the lymph node cells,
radioactivity measurements were performed. The activity was expressed as
the number of disintigrations per minute (DPM) and a stimulation index
(SI) was subsequently calculated for each group. The stimulation indices
of MTDID 7819CE at the three concentrations were 2.8, 5.0, and 6.0, and
the EC3 was determined to be 27.3%. The stimulation indices of MTDID
7819LS at the three concentrations were 3.6, 3.6, and 9.6; an EC3 could
not be determined, because all stimulation indices were >3. The
stimulation index of the concurrent positive control was 4.7, which is
very similar to the stimulation indices of the positive controls for the
other two portions of this study (4.6 and 6.5), in which other acrylate
monomers were tested. Based on the results of the study, the test
article should be considered to be a skin sensitizer, and the weight of
evidence indicates that classification as GHS Category 1B is
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