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Registration Dossier
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EC number: 206-108-6 | CAS number: 301-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Tin bis(2 -ethylhexanoate) was evaluated in the Guinea Pig Maximization test protocol. This study was assigned a reliability rating of K-1. Female Himalayan albino guinea pigs (SPF-quality, approximately 9 weeks old) were used in the study. Intradermal induction concentrations were 2% w/w tin bis(2 -ethylhexanoate) in propylene glycol and also 4% tin bis(2 -ethylhexanoate) in solution emulsified in 50:50 Freunds Complete Adjuvant. After one week, test animals were treated with 0.5 ml of a 50% solution of the test substance in propylene glycol applied epidermally on a moistened patch secured with tape between the injection sites. Control animals were treated with propylene glycol only. After 48 hours, the dressings and residual test material were removed, and the reaction sites were immediately assessed for erythema and edema. Test and control guinea pigs were challenged two weeks after the epidermal application with 10%, 5%, or 2% solutions of tin bis (2 -ethylhexanoate) in propylene glycol. Challenge applications were performed using Square chambers attached to Micropore tape and held in place with elastic bandages. Dressings and residual test substance were removed after 24 hours. Sites were assessed for redness and swelling 24 and 48 hours after removal of the dressing. In the challenge test, 20, 16 and 13 test animals showed a positive skin reaction in response to the 10%, 5% and 2% test substance concentrations, respectively. A sensitization rate of 85% was determined. [Air Products test]
Migrated from Short description of key information:
Guinea pig sensitisation: sensitising
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
This study indicates that tin bis(2 -ethylhexanoate) has dermal sensitization properties in studies in guinea pigs. Under GHS classification, tin bis(2 -ethylhexanoate) will be labeled (Warning; May cause allergic skin reaction).
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