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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 JAN 2010 - 19 APR 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: vapour pressure balance
Temp.:
ca. 25 °C
Vapour pressure:
ca. 0.3 Pa
Remarks on result:
other: Mean of 7 runs.

 Run

 Log10 [Vp(25°C)]
 1  -0.478
 2 -0.517 
 3 -0.554 
 4 -0.500 
 5 -0.487 
 6 -0.530 
 7

-0.552 

 Mean -0.517 
 Vapour Pressure  0.3 Pa

The vapor pressure determinations gave 0.30 ± 0.02 (mean ± 1 std. dev., n=7).

Conclusions:
The vapour pressure of the test material has been determined to be 0.3 Pa at 25°C.
Executive summary:

Vapor pressure was determined using the effusion vapor pressure balance method according to EU Method A.4 and GLP. The vapor pressure measurement was repeated for 7 runs, with same sample taken through temperature/vacuum cycles, to allow determination of any influence from volatile impurities. The mean and std. deviation of these seven determinations was 0.30 ± 0.02 Pa at 20°C , indicating very good consistency across the repeated measurements, and that the measurement was not influenced by presence of volatile impurities.

Description of key information

Vapor pressure was determined using the effusion vapor pressure balance method according to EU Method A.4 and GLP. The vapor pressure measurement was repeated for 7 runs, with same sample taken through temperature/vacuum cycles, to allow determination of any influence from volatile impurities. The mean and std. deviation of these seven determinations was 0.30 ± 0.02 Pa at 20°C , indicating very good consistency across the repeated measurements, and that the measurement was not influenced by presence of volatile impurities.

Key value for chemical safety assessment

Vapour pressure:
0.3 Pa
at the temperature of:
20 °C

Additional information