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EC number: 206-108-6 | CAS number: 301-10-0
Acute oral LD50: 5870 mg/kg bwAcute dermal LD50: >2000 mg/kg bw
The acute oral toxicity of tin bis(2 -ethylhexanoate) was evaluated in rats. The test material was administered without dilution at concentrations of 1.6, 3.2, 6.4, and 12.8 g/kg, via intragastric intubation, to four groups of 5 male rats. Animals were observed for 21-days post-exposure and mortalities were recorded daily. Animals in the 6.4 and 12.8 g/kg dose groups were observed to be listless following test material administration. Mortalities in these two dose groups occurred within the first four days following test substance administration. The single mortality in the 3.2 g/kg dose group occurred on day 12.
The oral LD50 (+95% confidence limits) of the test substance was reported as 5.87 (3.14-10.98) g/kg. The study was assigned a K-2 rating. [AME Test Report]
Groups of 6 male rats were exposed to the test substance at dose levels of 1.0, 1.7, 2.89, 4.91, and 8.35 g/kg bw. The test material was administered in paraffin oil as a single dose by oral gavage. Animals were observed animals for 14 days post-exposure and mortalities were recorded. At the end of the observation period, surviving animals were sacrificed and all animals underwent gross pathological examination. All mortalities occurred within 1 to 2 days after dosing. Clinical signs of toxicity included piloerection, soiled coat, hypokinesis and ataxia. No clinical signs persisted after 11 days post-exposure. Postmortem observations revealed fluid gut contents, pale kidneys, mottled liver, and patchy pink lung. The oral LD50 (+95% confidence limits) of the test substance was reported as 3.4 (2.5-4.8) g/kg bw. The study was assigned a K-2 rating. [Dow Test Report]
An acute dermal toxicity test was conducted with Fischer 344 rats to determine the potential for tin bis(2 -ethylhexanoate) to produce toxicity from a single topical application. Under the conditions of this study, the single dose acute dermal LD50 of the test substance was greater than 2,000 mg/kg of body weight in male and female rats. Two thousand milligrams of the test substance per kilogram of body weight was applied to the skin of ten healthy rats for 24 hours. The animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days. Body weights were recorded prior to application and again on Days 7 and 14 (termination). Necropsies were performed on all animals at terminal sacrifice. All animals survived exposure to the test substance, gained body weight, and appeared active and healthy during the study. Apart from dermal irritation (erythema) noted at the dose site of three female rats between Days 1 and 2, and for two male rats on Day 1, there were no other clinical findings recorded for any animal over the course of the study. No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period. The study was assigned a K-1 rating. [Dow Test Report]
Studies of the acute oral toxicity of tin bis(2 -ethylhexanoate) indicate that the material has an LD50 of 5870 mg/kg. The material is not classified according to GHS.
Tin bis(2 -ethylhexanoate) was not toxic following single limit dose (2000 mg/kg) dose application of the material to the skin of rats. No GHS category was assigned for dermal toxicity.
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