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EC number: 201-941-1 | CAS number: 89-80-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- D. L. J. Opdyke
- Year:
- 1 976
- Bibliographic source:
- Food and Cosmetics Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of Menthone in rabbits
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- trans-menthone
- EC Number:
- 201-941-1
- EC Name:
- trans-menthone
- Cas Number:
- 89-80-5
- Molecular formula:
- C10H18O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanone
- Details on test material:
- - IUPAC Name: (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one- Common Name: Menthone- InChI: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3- Smiles:C1([C@@H](CC[C@@H](C1)C)C (C)C)=O- Molecular formula:C10H18O - Molecular weight :154.2512 g/mole- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one- Common name: Menthone - Molecular formula: C10H18O- Molecular weight: 154.2512 g/mol- Smiles notation: C1([C@@H](CC[C@@H](C1)C)C(C)C)=O- InChl: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3- Substance type: Organic- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No 50 % mortality observed
- Mortality:
- No 50% mortality was observed in treated rabbits at 5000 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be >5000 mg/kg bw, when rabbits were treated with (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) by dermal application.
- Executive summary:
The acute dermal toxicity study was conducted by using (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) in rabbits atthe concentration of 5000 mg/kg bw. No mortality was observed in treated rabbits at 5000 mg/kg bw.Therefore, LD50 was considered to be >5000 mg/kg bw, when rabbits were treated with (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no.: 89-80-5) by dermal application.
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